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KMID : 0613820120220121729
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Journal of Life Science
2012 Volume.22 No. 12 p.1729 ~ p.1739
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Research Trends of Fermented Medicinal Herbs - Based on Their Clinical Efficacy and Safety Assessment
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Choi Yun-Kyung
Sul Jae-Uk
Park Seoul-Ki
Yu Sun-Nyoung
Kim Sang-Hun
Rhee Moon-Soo
Ahn Soon-Cheol
Shin Mi-Sook
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Abstract
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The aim of this study was to evaluate the clinical efficacy and safety of fermented medicinal herbs. A search of the China National Knowledge Infrastructure (CNKI), PubMed databases and Korean Journal of Oriental Medicine in 2000-2011 located 11 randomized controlled trials (RCTs) that investigated the clinical efficacy of fermented medicinal herbs. Domestic RCTs reported clinical efficacy on improvement of immune responses and clinical safety on usage of fermented medicinal herbs in subjects suffering from cerebral hemodynamics. Countries other than Chinareported studies on the cause of esophageal cancer and on local inflammatory reactions. In China, studies were reported on the effectiveness of fermented medicinal herbs on scapulohumeral periarthritis of the stasis type, chronic superficial gastritis, dysuria induced by benign prostatic hyperplasia of deficiency of kidney yang, diabetic nephropathy, essential hypertension, and benign prostate hyperplasia. These results indicate that fermented medicinal herbs have obvious clinical effects in some diseases and no adverse reactions. Therefore, we need to initiate more fermentation research with useful bacteria, fungi, and mushrooms to produce fermented medicinal herbs. Both governments and research authorities should focus on research involving fermentation of medicinal herbs.
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KEYWORD
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Fermented herbs, fermentation, clinical efficacy, safety assessment
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